#6768 TIO2/TI3C2 NANOCOMPOSITES FOR BILIRUBIN CLEARANCE FROM BLOOD

Abstract Background and Aims The artificial liver treatment based on blood purification is an important commonly used for failure. Aggressive management of hyperbilirubinemia one the key steps to reduce mortality in patients with Herein, targeting bilirubin nano-sized, we synthesized a TiO2/Ti3C2 nanocomposite from Ti3C2 MXenes via hydrothermal oxidation clearance whole blood. Method Firstly, MXene was prepared by hydrofluoric acid etching method reported our previous work [1]. Then, it transferred into Teflon-lined stainless-steel autoclaves (2 mg/ml, 30 ml) undergone process at 180 °C 6 h 12 h. nanocomposites were obtained after lyophilization. Hemocompatibility evaluation assays include hemolysis ratio test, complement activation (human fragment 5a (C5a)), contact (Thrombin–anti-thrombin (TAT) complex) platelet (platelet factor 4 (PF 4)) systemically conducted vitro evaluate feasibility novel (0.5 mg/ml) We evaluated adsorption capacity original (0 h) (6 concentration 0.5 respectively, solution (250 mg/l, 10 2 37 air bath away light. sphere-forming properties polyethersulfone (PES), material, first verified using liquid-liquid inversion method. Results showed better hemocompatibility than (Figure 1). capacities 354.11 mg/g, 492.83 mg/g 492.52 respectively. From h), rate improved 70.82% 98.57%. Therefore, chose verify PES. TiO2/Ti3C2-PES spheres constructed successfully More 3D porous structure surface uniform distribution (Ti element) substrate observed scanning electron microscope (SEM) images energy dispersive spectroscopy (EDS) mapping 2). Conclusion excellent capability, superior hemocompatibility, great application potential form hemoperfusion, which may provide promising choice performance enhancement characterized clearance. Importantly, above are adjustable heating temperature time period, other forms strategies target nano-sized worth being explored expected.